Publications | Hill Lab 1

Selected Publications

Phasic metabolic remodeling coordinates cardiac myofibroblast differentiation and function

Wells CK, Luque LG, Nguyen DC, Teer MS, Chen N, Martinez-Ondaro Y, Lorkiewicz PK, Singhal R, De Silva M, Hill BG.

Redox Biol. 2026 Oct 16;98:104441. doi: 10.1016/j.redox.2026.104441. Online ahead of print.

Reintroducing FABP5 in adulthood activates cell cycle in cardiomyocytes

Salama ABM, Ou Q, Dwenger M, Wells CK, Gebreil A, Miller J, Abou Farraj K, Nong Y, Wahid RM, Abdelhafez H, Arai M, Dastagir M, Khan MS, Mathew PR, Hamouda M, Baraka NM, Elhelaly WM, Rhamfield J, Kulkarni O, Huelsmann J, Taha S, Liu R, Bench S, Kang SW, Rodriguez V, Kraushaar D, Lee HS, Eberlin LS, Hill BG, Rosengart TK, Abouleisa RRE, Mohamed TMA.

Cardiovasc Res. 2026 Sep 18:cvag206. doi: 10.1093/cvr/cvag206. Online ahead of print.

Thermal environment and light exposure shape sleep-associated metabolic and thermoregulatory rhythms.

Gouwens KR, Nong Y, Hill BG, Nystoriak MA.

Am J Physiol Regul Integr Comp Physiol. 2026 Oct 1;331(4):R623-R632. doi: 10.1152/ajpregu.00061.2026. Epub 2026 Sep 11.

Dietary branched-chain amino acids modify the cardiac growth response to exercise in male mice

Fulghum KL, Collins HE, Hill BG.

J Mol Cell Cardiol. 2026 Jun 5;217:73-75. doi: 10.1016/j.yjmcc.2026.06.003. Online ahead of print.

TAK1 drives inflammatory fibroblast acquisition and shapes myocardial infarction responses in male mice

Nguyen DC, Stephan JK, Luque LG, Brainard RE, Brittian KR, Wells CK, Teer MS, Martinez-Ondaro Y, Gouwens KR, Little DT, Nong Y, Boyd NL, Kumar A, Jones SP, Singhal R, Hellmann J, Wysoczynski M, Hill BG.

Nat Commun. 2026 May 26. doi: 10.1038/s41467-026-73646-4. Online ahead of print

Ketone Bodies in Cardiovascular Disease: The Vasculature as a Therapeutic Target.

Challa AA, Hill BG, Nystoriak MA, Gouwens KR, Kalra DK.

JACC Basic Transl Sci. 2025 Jul 17;10(8):101328. doi: 10.1016/j.jacbts.2025.101328.

Pyruvate kinase splice variants in fibroblasts influence cardiac remodeling after myocardial infarction in male mice.

Wells CK, Nguyen DC, Brainard RE, McNally LA, De Silva M, Brittian KR, Garrett L, Taylor MS, Martinez-Ondaro Y, Howard C, Suluru S, Dassanayaka S, Mohamed TMA, Singhal R, Gibb AA, Lorkiewicz PK, Moore JB 4th, Jones SP, Hill BG.

J Mol Cell Cardiol. 2025 Jul 10;206:11-26. doi: 10.1016/j.yjmcc.2025.07.005.

Cardiac Ketone Body Oxidation Enhances Exercise Performance

Gouwens KR, Pena Calderin E, Okhiria J, Nguyen DC, Schulman-Geltzer EB, Martinez-Ondaro Y, De Silva M, Collins HE, Nong Y, Sears SM, Nystoriak MA, Hill BG.

Circ Res 2025 May 28. doi: 10.1161/CIRCRESAHA.125.326414.

Exercise-Stimulated Resolvin Biosynthesis in the Adipose Tissue Is Abrogated by High-Fat Diet-Induced Adrenergic Deficiency

Pena Calderin E, Zheng JJ, Boyd NL, Lynch W, Sansbury B, Spite M, Hill BG, Hellmann J.

Arterioscler Thromb Vasc Biol. 2025 May 8. doi: 10.1161/ATVBAHA.124.322234.

G-CSF-Induced Emergency Granulopoiesis Modulates Neutrophil Effector Function in Mice

Stephan JK, Knerr T, Wells CK, Gu Z, Johnson S, Jobe TK, Isaacs WS, Hill BG, Wysoczynski M.

Stem Cell Rev Rep. 2025 May;21(4):1113-1126. doi: 10.1007/s12015-025-10885-w.

Dietary Branched‐Chain Amino Acids Modify Postinfarct Cardiac Remodeling and Function in the Murine Heart

Nguyen DC, Wells CK, Taylor MS, Martinez-Ondaro Y, Singhal R, Brittian KR, Brainard RE, Moore JB, Hill BG.

Journal of the American Heart Association, Volume 14, Number 4, Published 14 February 2025

Phase partitioning of the neutrophil oxidative burst is controlled by accessory pathways of glucose metabolism and mitochondrial activity.

Jobe T, Stephan J, Wells CK, Lorkiewicz P, *Hill BG, and *Wysoczynski M

J Biol Chem 2025 Jan;301(1):108091. *co-corresponding authors

Myocardial Hyperemia via Cardiomyocyte Catabolism of β-Hydroxybutyrate.

Gouwens KR, Nong Y, Chen N, Schulman-Geltzer EB, Collins HE, Hill BG, Nystoriak MA.

Arteriosclerosis, Thrombosis, and Vascular Biology, Volume 45, Number 2, Published 12 December 2024

Intestine epithelial hypoxia inducible factor-1α overexpression ameliorates western diet-induced MASLD

Xu M, Taylor MS, Hill BG, Li X, Rouchka EC, McClain CJ, and Song M.

Hepatol Commun 2024 Nov 25;8(12):e0572. (in press)

Exercise-induced changes in myocardial glucose utilization during periods of active cardiac growth

Fulghum K, Collins HE, Lorkiewicz PK, Cassel T, Fan TWM, and Hill BG

J Mol Cell Cardiol 191: 50-62, 2024

Cardiac mitochondrial metabolism during pregnancy and the postpartum period.

Schulman-Geltzer EB, Fulghum KL, Singhal RA, Hill BG, and Collins HE

Am J Physiol Heart Circ Physiol 326(5): H1324-H1335, 2024

Coordinated metabolic responses facilitate cardiac growth in pregnancy and exercise.

Schulman-Geltzer EB, Collins HE, Hill BG, and Fulghum K

Curr Heart Fail Rep 20(5):441-450, 2023

The metabolic state of the heart regulates mitochondrial supercomplex abundance in mice.

Zheng YT, Gibb AA, Xu H, Liu SQ, and Hill BG

Redox Biol 63:102740, 2023

Interplay between exercise, circadian rhythm, and cardiac metabolism and remodeling.

Fulghum K and Hill BG.

Curr Opin Physiol 32: 100643, 2023.

Exercise-induced specialized proresolving mediators stimulate AMPK phosphorylation to promote mitochondrial respiration in macrophages.

Pena Calderin E, Zheng JJ, Boyd N, McNally L, Lorkiewicz P, Hill BG, and Hellmann J.

Mol Metab 66:101637, 2022.

Glutamine uptake and catabolism is required for myofibroblast formation and persistence.

Gibb AA, Huynh AT, Gaspar RB, Ploesch TL, Lombardi AA, Lorkiewicz PK, Lazaropoulos MP, Bedi K, Arany Z, Margulies KB, Hill BG, Elrod JW.

J Mol Cell Cardiol 172:78-89, 2022.

Influence of exercise on cardiac metabolism and resilience.

Gibb AA, Fulghum K, Hill BG, Quindry J, and Lopaschuk G.

Exercise Metabolism (pp. 263-292). The American Physiological Society, 2022.

Metabolic Signatures of Pregnancy-Induced Cardiac Growth.

Fulghum K, Smith JB, McNally LA, Brittian KR, Chariker J, Uchida S, Jones SP, Hill BG, Collins HE.

Am J Physiol Heart Circ Physiol 323(1):H146-H164, 2022.

Influence of biological sex and exercise on murine cardiac metabolism.

Fulghum K, Collins HE, Jones SP, and Hill BG.

J Sport Health Sci 11(4):479-494, 2022.

Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism.

Dwenger MM, Raph SM, Reyzer ML, Manier L, Wohl ZB, Ohanyn V, Moore JB, Hill BG, Caprioli RM, Bhatnagar A, and Nystoriak MA.

Nat Commun 13:2051, 2022.

Glutaminolysis is essential for myofibroblast persistence and in vivo targeting reverses fibrosis and cardiac dysfunction in heart failure.

Gibb AA, Murray E, Huynh A, Gaspar R, Ploesch T, Lombardi A, Lorkiewicz P, Roy R, Arany Z, Kelly DP, Margulies K, Hill BG, Elrod J.

Circulation 145(21):1625-1628, 2022.

Metabolic determinants of cardiomyocyte proliferation.

Mohamed TMA, Abouleisa REE, and Hill BG.

Stem Cells 40(5):458-467, 2022.

In vivo deep network tracing reveals phosphofructokinase-mediated coordination of biosynthetic pathway activity in the myocardium.

Fulghum KL, Audam T, Lorkiewicz PK, Zheng Y, Merchant M, Cummins TD, Dean WL, Cassel TA, Fan TWM, and Hill BG.

J Mol Cell Cardiol 162: 32-42, 2022.

In vivo deep network tracing reveals phosphofructokinase-mediated coordination of biosynthetic pathway activity in the myocardium.

Fulghum KL, Audam T, Lorkiewicz PK, Zheng Y, Merchant M, Cummins TD, Dean WL, Cassel TA, Fan TWM, and Hill BG.

J Mol Cell Cardiol 162: 32-42, 2022.

Cell cycle induction in human cardiomyocytes is dependent on biosynthetic pathway activation.

Abouleisa R, McNally LA, Salama AM, Hammad SK, Ou Q, Wells C, Lorkiewicz PK, Bolli R, Mohamed TMA, and Hill BG.

Redox Biol 46:102094, 2021.

Fine particulate matter (PM2.5) inhalation-induced alterations in the plasma lipidome as promoters of vascular inflammation and insulin resistance.

Hill BG, Rood B, Ribble A, and Haberzettl P.

Am J Physiol Heart Circ Physiol 320(5):H1836-H1850, 2021.

Endothelial progenitor cells as critical mediators of environmental air pollution-induced cardiovascular toxicity

Singh P, O’Toole T, Conklin DJ, Hill BG, and Haberzettl P.

Am J Physiol Heart Circ Physiol 320(4):H1440-H1455, 2021.

Considerations for using isolated cell systems to understand cardiac metabolism and biology.

McNally LA, Altamimi T, Fulghum K, and Hill BG.

J Mol Cell Cardiol 153:26-41, 2020.

Exercise promotes resolution of inflammation by catecholamine-mediated stimulation of resolvin D1 biosynthesis.

Zheng JJ, Pena Calderin E, Hill BG, Bhatnagar A, and Hellmann J.

J Immunol 203(11):3013-3022, 2019

Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation.

Lombardi AA, Gibb AA, Arif E, Kolmetzky DW, Luongo TS, Jadiya P, Lorkiewicz PK, Hajnoczky G, Vondriska TM, Murphy E, Hill BG, and Elrod JW.

Nat Commun 10(1):4409, 2019.

Integration of flux measurements and pharmacological controls to optimize stable isotope-resolved metabolomics workflows and interpretation.

Lorkiewicz PK, Gibb AA, Rood BR, He, L, Zheng YT, Clem BF, Zhang X, and Hill BG.

Sci Rep 9: 13705, 2019.

A physiological biomimetic culture system for pig and human heart slices.

Ou Z, Jacobson Z, Abouleisa RRE, Tang XL, Hindi SM, Kumar A, Ivey KN, Giridharan G, Al-Baz A, Brittian K, Rood B, Lin YH, Watson SA, Perbellini F, McKinsey TA, Hill BG, Jones SP, Terracciano CM, Bolli R, and Mohamed TMA.

Circ Res 125(6):628-642, 2019.

A metabocentric view of cardiac remodeling.

Hill BG.

Curr Opin Physiol 10:1-6, 2019.

Mitochondria-associated lactate dehydrogenase is not a biologically significant contributor to striated muscle metabolism.

Fulghum K, Rood B, Shang V, McNally L, Riggs DW, Zheng YT, and Hill BG.

Redox Biol 24: 101177, 2019.

Cardiac mesenchymal cells from diabetic mice are ineffective for cell therapy-mediated myocardial repair.

Mehra PM, Guo Y, Nong Y, Lorkiewicz PK, Nasr M, Li Q, Muthusamy S, Bradley JA, Bhatnagar A, Wysoczynski M, Bolli R, and Hill BG.

Basic Res Cardiol 113(6):46, 2018.

Metabolic mechanisms of exercise-induced cardiac growth.

Fulghum K and Hill BG.

Front Cardiovasc Med 5: 127, 2018.

Metabolic coordination of physiological and pathological cardiac remodeling.

Gibb AA and Hill BG.

Circ Res 123: 107-128, 2018.

Cardiac-specific overexpression of aldehyde dehydrogenase 2 exacerbates cardiac remodeling in response to pressure overload.

Dassanayaka S, Zheng YT, Gibb AA, Cummins TD, McNally LA, Brittian KR, Jagatheesan G, Audam TN, Long BW, Brainard RE, Jones SP, and Hill BG.

Redox Biol 17: 440-449, 2018.

TAK1 is a key regulator of skeletal muscle mass and mitochondrial function.

Hindi SM, Sato S, Xiong G, Bohnert KR, Gibb AA, Gallot YS, McMillan JD, Hill BG, Uchida S, and Kumar A.

JCI Insight 3(3), pii:98441, 2018.

High throughput measurement of metabolism in planarians reveals activation of glycolysis during regeneration.

Osuma EA, Riggs DW, Gibb AA, and Hill BG.

Regeneration 5(1): 78-86, 2018.

Exercise-induced changes in glucose metabolism promote physiological cardiac growth.

Gibb AA, Epstein PN, Uchida S, McNally LA, Zheng Y, Obal D, Kartragadda K, Trainor P, Brittian KR, Tseng M, Jones SP, Bhatnagar A, and Hill BG.

Circulation 136: 2144-2157, 2017.

Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytes.

Gibb AA, Lorkiewicz P, Zheng YT, Zhang X, Jones SP, Bhatnagar A and Hill BG.

Biochem J 474: 2785-2801, 2017.

FVB/NJ mice are a useful model for examining cardiac adaptations to treadmill exercise.

Gibb AA, McNally LA, Riggs DW, Conklin DJ, Bhatnagar A, and Hill BG.

Front Physiol 7:636, 2016.

Type 2 diabetes dysregulates glucose metabolism in cardiac progenitor cells.

Salabei JK, Lorkiewicz PK, Mehra P, Gibb AA, Haberzettl P, Hong KU, Wei X, Zhang X, Li Q, Wysoczynski M, Bolli R, Bhatnagar A, and Hill BG.

J Biol Chem 291(26): 13634-13648, 2016.

CCR7 maintains non-resolving adipose and lymph node inflammation in obesity.

Hellmann J, Holden CR, Sansbury BE, Tang Y, Wong B, Wysoczynski M, Rodriguez J, Bhatnagar A, Hill BG, and Spite M.

Diabetes 65(8): 2268-81, 2016.

Glutamine regulates cardiac progenitor cell metabolism and proliferation.

Salabei JK, Lorkiewicz PK, Holden CR, Li Q, Hong KU, Bolli R, Bhatnagar A, and Hill BG.

Stem Cells 33(8): 2613-27, 2015.

High glucose induces mitochondrial dysfunction independent of protein O-GlcNAcylation.

Dassanayaka S, Readnower RD, Long BW, Aird AL, Zheng YT, Salabei JK, Facundo H, Hill BG*, and Jones SP*.

Biochem J 467:113-124, 2015*Co-corresponding authors

Metabolic remodeling of white adipose tissue in obesity.

Cummins TD, Holden CR, Sansbury BE, Gibb AA, Shah J, Zafar N, Tang Y, Hellmann J, Rai SN, Spite M, Bhatnagar A, and Hill BG.

Am J Physiol Endocrinol Metab 307:E262-E277, 2014.

Regulation of obesity and insulin resistance by nitric oxide.

Sansbury BE and Hill BG.

Free Radic Biol Med 79: 383-399, 2014.

Metabolomic analysis of pressure-overloaded and infarcted mouse hearts.

Sansbury BE, DeMartino AM, Xie Z, Brooks AC, Brainard RE, Watson LJ, Holden CR, DeFilippis AP, Cummins TD, Harbeson MA, Brittian KR, Prabhu SD, Bhatnagar A, Jones SP, and Hill BG.

Circ Heart Fail 7:634-642, 2014.

Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis.

Salabei JK, Gibb AA, and Hill BG.

Nat Protoc 9(2): 421-438, 2014.

Cardiomyocyte Ogt is essential for postnatal viability.

Watson LJ, Long BL, De Martino AM, Brittian KR, Readnower RD, Brainard RE, Cummins TD, Annamalai L, Hill BG, and Jones SP.

Am J Physiol Heart Circ Physiol 306(1):H142-53, 2014.

Mitochondrial fission regulates platelet-derived growth factor-induced changes in cell proliferation and bioenergetics.

Salabei JK and Hill BG.

Redox Biol 1(1):542–55, 2013.

Implications of autophagy for vascular smooth muscle cell function and plasticity.

Salabei JK and Hill BG.

Free Radic Biol Med 65C:693-703, 2013.

PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype transition and resistance to oxidative stress.

Salabei JK, Cummins TD, Singh M, Jones SP, Bhatnagar A, and Hill BG.

Biochem J 451(3):375-388, 2013.

Oxidized lipids activate autophagy in a JNK-dependent manner by stimulating the endoplasmic reticulum stress response.

Haberzettl P and Hill BG.

Redox Biol 1(1): 56-66, 2013.

Standardized Bioenergetic Profiling of Adult Mouse Cardiomyocytes.

Readnower R, Brainard R, Hill BG, and Jones SP.

Physiol Genomics 44:1208-13, 2012.

Integration of cellular bioenergetics with mitochondrial quality control and autophagy.

Hill BG, Benavides G, Lancaster J, Ballinger S, Dell’Italia L, Zhang J, and Darley-Usmar VM.

Biol Chem 393(12):1485–1512, 2012.

Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipose tissue phenotype.

Sansbury BE, Cummins TD, Tang Y, Hellman J, Holden CR, Harbeson M, Chen T, Patel RP, Spite M, Bhatnagar A, and Hill BG.

Circ Res. 111: 1176-1189, 2012.